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Search Results for " endoplasmic reticulum protein 5 "

2

抑制剂 & 化合物

2

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T63008	PERK-IN-5
	PERK-IN-5 是一种高度选择性的、高效的、口服具有活力的蛋白激酶 R 样内质网 (ER) 激酶 (PERK) 抑制剂，能够作用于 PERK (IC50: 2 nM) 与 p-eIF2α (IC50: 9 nM)。在 786-O 肾细胞癌异种移植瘤模型中，PERK-IN-5 可以明显抑制肿瘤生长。
T63007	(S)-PERK-IN-5
	(S)-PERK-IN-5 是 PERK-IN-5 的 S 对映体。(S)-PERK-IN-5 是一种 PERK 抑制剂 (IC50: 0.101-0.250 μM)。

化合物

Cat.No: T63008

Cat.No: T63007

Cat. No.	Product Name	Target	Signaling Pathways
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

天然产物

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: TN6458

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01124	PDIA6 Protein, Human, Recombinant (His) Thioredoxin Domain-Containing Protein 7,P5...	Human	Human Cells
	Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA...
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His) EIF4G,eIF-4-gamma 1,Eukaryotic translation initiation factor...	Human	Yeast
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation.
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) eIF-4G 1,EIF4G,Eukaryotic translation initiation factor 4 ga...	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation.
TMPY-03856	SEZ6L2 Protein, Human, Recombinant (His) PSK-1,seizure related 6 homolog (mouse)-like 2	Human	HEK293
	SEZ6L2, also known as PSK-1, belongs to the SEZ6 family. It contains 3 CUB domains and 5 Sushi (CCP/SCR) domains. SEZ6L2 may contribute to specialized endoplasmic reticulum functions in neurons.SEZ6L2 presents on the surface of lung cancer cells. SEZ6L2 should be a useful prognostic marker of lung cancers. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer.
TMPY-02758	ENTPD5 Protein, Human, Recombinant (His) NTPDase-5,ectonucleoside triphosphate diphosphohydr...	Human	Baculovirus-Insect Cells
	Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. It is Up-regulated in PTEN-deficient cells. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation an...
TMPY-04276	ENTPD5 Protein, Mouse, Recombinant (His) NTPDase-5,AI196558,ER-UDPase,ecto...	Mouse	Baculovirus-Insect Cells
	Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed in response to phosphoinositide 3-kinase (PI3K) signaling. Activation of PI3K results in FOXO phosphorylation by AKT1 and loss of ENTPD5 transcriptional repression. It is Up-regulated in PTEN-deficient cells. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation an...
TMPY-02001	RTN4 Protein, Human, Recombinant (GST) UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X,NSP,UNG1...	Human	E. coli
	Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ...
TMPY-01732	LRPAP1 Protein, Mouse, Recombinant (His) C77774,AU042172,RAP,AI790446,low density lipoprotein	Mouse	HEK293
	Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts a...
TMPY-01233	LRPAP1 Protein, Human, Recombinant (His) HBP44,MYP23,low density lipoprotein receptor-relate...	Human	HEK293
	Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts a...
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His) GP180,B220,L-CA,protein tyrosine phosphatase, recep...	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc) cAMP-dependent transcription factor ATF-4,Activating transcr...	Rat	E. coli
	Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR). Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, am...
TMPY-05387	SLAMF7 Protein, Human, Recombinant (hFc) SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC	Human	HEK293
	SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule...
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05547	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A	Human	HEK293
	SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule...
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...	Human	HEK293
	Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogica...
TMPK-01357	SIRP alpha V5 Protein, Human, Recombinant (His & Avi) MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363	SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...	Human	HEK293
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.

重组蛋白

PDIA6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01124

Species: Human

Expression System: Human Cells

EIF4G1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01313

Species: Human

Expression System: Yeast

EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)

Cat.No: TMPH-01312

Species: Human

Expression System: E. coli

SEZ6L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03856

Species: Human

Expression System: HEK293

ENTPD5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02758

Species: Human

Expression System: Baculovirus-Insect Cells

ENTPD5 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04276

Species: Mouse

Expression System: Baculovirus-Insect Cells

RTN4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02001

Species: Human

Expression System: E. coli

LRPAP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01732

Species: Mouse

Expression System: HEK293

LRPAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01233

Species: Human

Expression System: HEK293

CD45 Protein, Human, Recombinant (aa 1-529, His)

Cat.No: TMPY-05308

Species: Human

Expression System: HEK293

ATF-4 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03274

Species: Rat

Expression System: E. coli

SLAMF7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05387

Species: Human

Expression System: HEK293

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05547

Species: Human

Expression System: HEK293

SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05498

Species: Human

Expression System: HEK293

SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01357

Species: Human

Expression System: HEK293

SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01363

Species: Human

Expression System: HEK293

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